Items 201 ~ 220 of 5552, Page 11 of 279 
  08/30/2018 N Engl J Med 2018; 379:856-868 - Health and Science
Langerhans-Cell Histiocytosis
- Authors reviewed the history of LCH and discuss recent biologic insights that are poised to propel the treatment of LCH beyond an empirical roulette wheel into the era of personalized medicine.
  08/23/2018 N Engl J Med 2018; 379:743-752 - Health and Science
Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth
- Heat-stable carbetocin was noninferior to oxytocin for the prevention of blood loss of at least 500 ml or the use of additional uterotonic agents. Noninferiority was not shown for the outcome of blood loss of at least 1000 ml; low event rates for this outcome reduced the power of the trial.
  08/30/2018 N Engl J Med 2018; 379:846-855 - Health and Science
Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis
- In a phase 2 trial involving patients with progressive multiple sclerosis, ibudilast was associated with slower progression of brain atrophy than placebo but was associated with higher rates of gastrointestinal side effects, headache, and depression.
  03/01/2018 N Engl J Med 2018; 378:829-839 - Health and Science
Balanced Crystalloids versus Saline in Critically Ill Adults
- Among critically ill adults, the use of balanced crystalloids for intravenous fluid administration resulted in a lower rate of the composite outcome of death from any cause, new renal-replacement therapy, or persistent renal dysfunction than the use of saline.
  05/03/2018 N Engl J Med 2018; 378:1691-1703 - Health and Science
Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer''s Disease
- Verubecestat did not reduce cognitive or functional decline in patients with mild-to-moderate Alzheimer뭩 disease and was associated with treatment-related adverse events.
  09/06/2018 N Engl J Med 2018; 379:981-984 - Health and Science
High-Risk Clonal Hematopoiesis as the Origin of AITL and NPM1-Mutated AML
- Possible Steps in the Development of Two Cancers in a Patient with Extensive CHIP
  08/16/2018 N Engl J Med 2018; 379:686-688 - Health and Science
Digesting New Developments in Biosensors
- In a recent article, Mimee, Nadeau, and colleagues tackle this challenge by leveraging the flexibility of synthetic biology and engineering to create a modular, internal, continuous-measurement device that they call the ingestible micro-bio-electronic device (IMBED). They created and tested the device in three steps and showed the utility of their system for measuring heme released from blood within the gastrointestinal tract in a porcine model.
  08/26/2018 N Engl J Med 2018: DOI: 10.1056/NEJMoa1804988 - Health and Science
Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus
- Aspirin use prevented serious vascular events in persons who had diabetes and no evident cardiovascular disease at trial entry, but it also caused major bleeding events. The absolute benefits were largely counterbalanced by the bleeding hazard.
  08/23/2018 N Engl J Med 2018; 379:711-721 - Health and Science
A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest
- In adults with out-of-hospital cardiac arrest, the use of epinephrine resulted in a significantly higher rate of 30-day survival than the use of placebo, but there was no significant between-group difference in the rate of a favorable neurologic outcome because more survivors had severe neurologic impairment in the epinephrine group.
  05/31/2018 N Engl J Med 2018; 378:2105-2114 - Health and Science
A Randomized Trial of Early Endovenous Ablation in Venous Ulceration
- Early endovenous ablation of superficial venous reflux resulted in faster healing of venous leg ulcers and more time free from ulcers than deferred endovenous ablation. (Funded by the National Institute for Health Research Health Technology

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