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1. Effect of Aspirin on Disability-free Survival in the Healthy Elderly - 09/16/2018
 The New England Journal of Medicine (Massachusetts Medical Society)
  Aspirin use in healthy elderly persons did not prolong disability-free survival over a period of 5 years but led to a higher rate of major hemorrhage than placebo.
2. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly - 09/16/2018
 The New England Journal of Medicine (Massachusetts Medical Society)
  Higher all-cause mortality was observed among apparently healthy older adults who received daily aspirin than among those who received placebo and was attributed primarily to cancer-related death.
3. Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly - 09/16/2018
 The New England Journal of Medicine (Massachusetts Medical Society)
  The use of low-dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in a significantly lower risk of cardiovascular disease than placebo
4. NIH gets $2 billion boost in final 2019 spending bill - 09/14/2018
 American Association for the Advancement of Science (AAAS)
  By Jocelyn KaiserSep. 14, 2018 Congress has approved a $2 billion raise, to $39.1 billion, for the National Institutes of Health (NIH) in a 2019 spending bill approved by House of Representatives and Senate negotiators last night.
5. As massive Zika vaccine trial struggles, researchers revive plan to intentionally infect humans - 09/12/2018
 American Association for the Advancement of Science (AAAS)
  By Jon Cohen, Sep. 12, 2018
6. Universities are worse than drug companies at reporting clinical trial results - 09/12/2018
 American Association for the Advancement of Science (AAAS)
  By Tania Rabesandratana, Sep. 12, 2018 Almost 90% of academic clinical trials are not reported promptly to European registry
7. Coronary CT Angiography and 5-Year Risk of Myocardial Infarction - 09/06/2018
 N Engl J Med 2018; 379:924-933
  In this trial, the use of CTA in addition to standard care in patients with stable chest pain resulted in a significantly lower rate of death from coronary heart disease or nonfatal myocardial infarction at 5 years than standard care alone, without resulting in a significantly higher rate of coronary angiography or coronary revascularization.
8. How does exercise keep your brain young? - 09/06/2018
 American Association for the Advancement of Science
  A study published today in Science offers some new clues. In mice that mimic a severe, genetic form of Alzheimer'' disease, a combination of treatments that prompt the growth of new brain cells and protect them from damage can mimic the beneficial effects of exercise in preventing memory decline. So could we someday bottle the effects of exercise to treat Alzheimer? And if so, what exactly would we need to bottle? Here is a rundown of what we know, and what is still controversial.
9. New gene-editing treatment might help treat a rare disorder, hints first human test - 09/05/2018
 American Association for the Advancement of Science
  The first test of a new gene-editing tool in people has yielded early clues that the strategy, an infusion that turns the liver into an enzyme factory, could help treat a rare, inherited metabolic disorder.
10. Spurred by opioid epidemic, new pain drugs may lower the risk of overdose and addiction - 08/29/2018
 American Association for the Advancement of Science
  As the opioid crisis continues to ravage U.S. communities, scientists and drug companies have intensified their efforts to develop safer and less addictive pain medications.
11. Arginase upregulation and eNOS uncoupling contribute to impaired endothelium-dependent vasodilation in a rat model of intrauterine growth restriction - 08/29/2018
 Regulatory, Integrative and Comparative Physiology
12. Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest - 08/28/2018
 JAMA. 2018;320(8):769-778
  A strategy of initial laryngeal tube insertion, compared with endotracheal intubation, was associated with greater likelihood of 72-hour survival, but given limitations in study design and findings, additional research is warranted.
13. A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure - 08/27/2018
 Heart and Circulatory Physiology
14. A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest - 08/23/2018
 N Engl J Med 2018; 379:711-721
  In adults with out-of-hospital cardiac arrest, the use of epinephrine resulted in a significantly higher rate of 30-day survival than the use of placebo, but there was no significant between-group difference in the rate of a favorable neurologic outcome because more survivors had severe neurologic impairment in the epinephrine group.
15. Potential Impact of ACC/AHA Hypertension Guideline on Normotensive CAD Patients - 08/23/2018
 American College of Cardiology (ACC)
  What is the relationship between blood pressure (BP) and cardiovascular events in real-life patients with coronary artery disease (CAD) with newly diagnosed hypertension, based on the 2017 American College of Cardiology/American Heart Associatio...
16. Sarcopenic Obesity and Cardiovascular Disease in Older Adults - 08/23/2018
 American College of Cardiology (ACC)
  Obesity rates defined using body mass index (BMI) exceed 40% in adults aged 65 years and older. However, BMI is a poor measure for the ascertainment of adiposity because its sensitivity drops markedly with increasing age.
17. Impact of PCI on Exercise Hemodynamics in Stable CAD Patients - 08/23/2018
 American College of Cardiology (ACC)
  What is the impact of percutaneous coronary intervention (PCI) on exercise responses in the coronary circulation, the microcirculation, and systemic hemodynamics in patients with stable coronary artery disease (CAD)?
18. Bioprosthetic Aortic Valve Structural Valve Deterioration - 08/23/2018
 American College of Cardiology (ACC)
  What are the rate, timing, and predictors of echo/Doppler-defined hemodynamic valve deterioration (HVD) after surgical bioprosthetic aortic valve replacement (AVR), and how does HVD influence outcomes?
19. Intensive Lifestyle Intervention and Cerebral Blood Flow - 08/22/2018
 American College of Cardiology (ACC)
  Study Question: What is the effect of weight loss on cerebral blood flow in middle-aged and older adults with type 2 diabetes mellitus?
20. VAcuuM asPIration thrombus REemoval 3 - 08/09/2018
 American College of Cardiology (ACC)
  The goal of the VAMPIRE 3 trial was to evaluate distal filter protection compared with conventional percutaneous coronary intervention (PCI) among patients with attenuated plaque 5 mm in length on the incidence of no-reflow.
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